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KMID : 0603820140200030156
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Journal of Experimental & Biomedical Science
2014 Volume.20 No. 3 p.156 ~ p.161
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Effects of Dietary from Safflower Bud on the Osteoporosis in Ovariectomized Rats
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Lim Seul-Ki
Kim Dong-Il
Park Min-Jung
Choi Joo-Hee
Kim Young-Kuk
Lee An-Chul
Choi Mi-Young
Park Soo-Hyun
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Abstract
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It has been reported that safflower seeds have preventive effects against osteoporosis. Recently, safflower buds (SB) were found to have more useful functional ingredients than safflower seeds. In the current study, we evaluated the anti-osteoporosis effects of SB diet in ovariectomized (OVX) rats. The rats were divided into five groups; sham operated group, OVX alone group, OVX plus 17β-estradiol (E2 10 μg/kg, i.p.) and OVX plus SB diet feeding group (0.3% or 1%). Feeding of SB diet (0.3% or 1%) to OVX rats markedly increased bone mineral density (BMD) of femurs, compared to the OVX group. The OVX rats exhibited a marked increase in trabecular separation (Tb.Sp) and this change was inhibited by the feeding of SB diet, similar to that seen with OVX+E2 group. Moreover, feeding of SB diet to OVX rats decreased the markers of bone turnover, including osteocalcin and alkaline phosphatase (ALP). These results suggest that SB extract has a bone sparing effect in OVX-induced trabecular bone loss and prevents deterioration of bone microarchitecture by suppressing the rate of bone turnover. Therefore, SB may be useful for preserving bone mass and structure in estrogen deficient women with a potential role in reducing postmenopausal osteoporosis.
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KEYWORD
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Ovariectomized rats, Safflower bud, Bone biomechanics, Bone turnover
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